Fungal indole alkaloid biosynthesis: Genetic and biochemical investigation of the tryptoquialanine pathway in penicillium aethiopicum
Tremorgenic mycotoxins are a group of indole alkaloids which include the quinazoline-containing tryptoquivaline (2) that are capable of eliciting intermittent or sustained tremors in vertebrate animals. The biosynthesis of this group of bioactive compounds, which are characterized by an acetylated quinazoline ring connected to a 6-5-5 imidazoindolone ring system via a 5-membered spirolactone, has remained uncharacterized. Here, we report the identification of a gene cluster (tqa) from P....[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of the American Chemical Society|
|01_Gao_Fungal_indole_alkaloid_2011.pdf||5.01 MB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.