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Fungal indole alkaloid biosynthesis: Genetic and biochemical investigation of the tryptoquialanine pathway in penicillium aethiopicum

Gao, Xue; Chooi, Yit-Heng; Ames, Brian D; Wang, Peng; Walsh, Christopher T; Tang, Yi


Tremorgenic mycotoxins are a group of indole alkaloids which include the quinazoline-containing tryptoquivaline (2) that are capable of eliciting intermittent or sustained tremors in vertebrate animals. The biosynthesis of this group of bioactive compounds, which are characterized by an acetylated quinazoline ring connected to a 6-5-5 imidazoindolone ring system via a 5-membered spirolactone, has remained uncharacterized. Here, we report the identification of a gene cluster (tqa) from P....[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja1101085


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