Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an a-hydroxylation-dependent claisen-like cyclization catalyzed by a dimanganese thioesterase
The linear tetracyclic TAN-1612 (1) and BMS-192548 (2) were isolated from different filamentous fungal strains and have been examined as potential neuropeptide Y and neurokinin-1 receptor antagonists, respectively. Although the biosynthesis of fungal aromatic polyketides has attracted much interest in recent years, the biosynthetic mechanism for such naphthacenedione-containing products has not been established. Using a targeted genome mining approach, we first located the ada gene cluster...[Show more]
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|Source:||Journal of the American Chemical Society|
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