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Hernias and Ewings sarcoma family of tumours: a pooled analysis and meta-analysis

Valery, Patricia C; Holly, Elizabeth A; Williams, Gail; Kreiger, Nancy; Bailyn, C; Sleigh, Adrian

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Background: Ewing's sarcoma family of tumours has been associated with a history of hernia and with a parental occupation of farming. However, the causes of these tumours remain unknown. We therefore aimed to investigate the association between hernia and Ewing's sarcoma family of tumours. Methods: We did a pooled analysis of two case-control studies and a meta-analysis of three case-control studies of Ewing's sarcoma family of tumours that had adequate information on history of hernia. The...[Show more]

dc.contributor.authorValery, Patricia C
dc.contributor.authorHolly, Elizabeth A
dc.contributor.authorWilliams, Gail
dc.contributor.authorKreiger, Nancy
dc.contributor.authorBailyn, C
dc.contributor.authorSleigh, Adrian
dc.date.accessioned2015-12-13T22:49:36Z
dc.identifier.issn1470-2045
dc.identifier.urihttp://hdl.handle.net/1885/80615
dc.description.abstractBackground: Ewing's sarcoma family of tumours has been associated with a history of hernia and with a parental occupation of farming. However, the causes of these tumours remain unknown. We therefore aimed to investigate the association between hernia and Ewing's sarcoma family of tumours. Methods: We did a pooled analysis of two case-control studies and a meta-analysis of three case-control studies of Ewing's sarcoma family of tumours that had adequate information on history of hernia. The primary endpoint was development of a tumour from the Ewing's sarcoma family. 138 patients with such a tumour and 574 controls were included in the pooled analysis, and 357 patients with these tumours and 745 controls were included in the meta-analysis. Risk was assessed by an odds ratio (OR) and 95% CI by use of multivariate analysis with unconditional logistic regression for the pooled analysis and random effects model for the meta-analysis. Findings: Pooled analysis showed that children with Ewing's sarcoma family of tumours were more likely to have had an umbilical hernia than were controls (odds ratio [OR] 3·3 [95% CI 1·3-8·0]). Meta-analysis showed that children with Ewing's sarcoma family of tumours were more likely to have had a hernia (3·2 [1·9-5·7]). Interpretation: Ewing's sarcoma family of tumours and hernias (particularly inguinal hernias) have common embryological pathways of neuroectodermal origin, and environmental factors, such as farming, might link the two entities.
dc.publisherLancet Publishing Group
dc.sourceLancet Oncology, The
dc.subjectKeywords: agricultural worker; article; case control study; clinical trial; confidence interval; controlled clinical trial; controlled study; disease association; environmental factor; Ewing sarcoma; hernia; human; information retrieval; inguinal hernia; logistic r
dc.titleHernias and Ewings sarcoma family of tumours: a pooled analysis and meta-analysis
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume6
dc.date.issued2005
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationMigratedxPub8874
local.type.statusPublished Version
local.contributor.affiliationValery, Patricia C, Queensland Institute of Medical Research
local.contributor.affiliationHolly, Elizabeth A, University of California
local.contributor.affiliationSleigh, Adrian, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWilliams, Gail, University of Queensland
local.contributor.affiliationKreiger, Nancy, University of Toronto
local.contributor.affiliationBailyn, C, Yale University
local.description.embargo2037-12-31
local.bibliographicCitation.startpage485
local.bibliographicCitation.lastpage490
local.identifier.doi10.1016/S1470-2045(05)70242-4
dc.date.updated2015-12-11T10:36:39Z
local.identifier.scopusID2-s2.0-21344453299
CollectionsANU Research Publications

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