Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440
Echinocandins are a family of fungal lipidated cyclic hexapeptide natural products. Due to their effectiveness as antifungal agents, three semisynthetic derivatives have been developed and approved for treatment of human invasive candidiasis. All six of the amino acid residues are hydroxylated, including 4R,5R-dihydroxy-l-ornithine, 4R-hydroxyl-l-proline, 3S,4S-dihydroxy-l- homotyrosine, and 3S-hydroxyl-4S-methyl-l-proline. We report here the biosynthetic gene cluster of echinocandin B 1 from...[Show more]
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|Source:||Journal of the American Chemical Society|
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