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The effects of substrate orientation on the mechanism of a phosphotriesterase

Jackson, Colin; Liu, Jian-Wei; Coote, Michelle; Ollis, David


While the underlying chemistry of enzyme-catalyzed reactions may be almost identical, the actual turnover rates of different substrates can vary significantly. This is seen in the turnover rates for the catalyzed hydrolysis of organophosphates by the bacterial phosphotriesterase OpdA. We investigate the variation in turnover rates by examining the hydrolysis of three classes of substrates: phosphotriesters, phosphothionates, and phosphorothiolates. Theoretical calculations were used to analyze...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Organic and Biomolecular Chemistry
DOI: 10.1039/b512399b


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