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Elucidation of piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of a-pyridone ring formation

Liu, Qian; Yao, Fen; Chooi, Yit-Heng; Kang, Qianjin; Xu, Wei; Li, Yanran; Shao, Yucheng; Shi, Yuefeng; Deng, Zixin; Tang, Yi; You, Delin


Piericidins are a class of α-pyridone antibiotics that inhibit mitochondrial respiratory chain and exhibit antimicrobial, antifungal, and antitumor activities. Sequential analysis of Streptomyces piomogeues var. Hangzhouwanensis genome revealed six modul

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Chemistry and Biology
DOI: 10.1016/j.chembiol.2011.12.018


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