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Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi

Chooi, Yit-Heng; Fang, Jinxu; Liu, Hong; Filler, Scott G; Wang, Pin; Tang, Yi


Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent.

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Organic Letters
DOI: 10.1021/ol303435y


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