Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi
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Chooi, Yit-Heng; Fang, Jinxu; Liu, Hong; Filler, Scott G; Wang, Pin; Tang, Yi
Description
Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent.
Collections | ANU Research Publications |
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Date published: | 2013 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/80435 |
Source: | Organic Letters |
DOI: | 10.1021/ol303435y |
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01_Chooi_Genome_mining_of_a_prenylated_2013.pdf | 1.23 MB | Adobe PDF | Request a copy |
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