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Chronic fluoxetine treatment increases daytime melatonin synthesis in the rodent

Reierson, Gillian W.; Mastronardi, Claudio; Licinio, Julio; Wong, Ma-Li


Circadian rhythm disturbances can occur as part of the clinical symptoms of major depressive disorder and have been found to resolve with antidepressant therapy. The pineal gland is relevant to circadian rhythms as it secretes the hormone melatonin following activation of the cyclic adenosine monophosphate (cAMP) signaling cascade and of arylalkylamine N-acetyltransferase (AA-NAT), the rate-limiting enzyme for its synthesis. Cyclic AMP is synthesized by adenylate cyclases (AC) and degraded by...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Clinical Pharmacology: Advances and Applications


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