Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat
PURPOSE. To relate the oxygen environment of the retina to photoreceptor stability, protection, and function in the P23H rat. METHODS. Heterozygote P23H-3 (Line 3) rats were studied. Photoreceptor death rates were assessed with the TUNEL technique for detection of fragmenting DNA, in a developmental series from postnatal day (P)16 to P105 (adult). In adult retinas, trophic factor status was assessed with immunohistochemistry, intraretinal oxygen environment with O2-sensing electrodes, and...[Show more]
|Collections||ANU Research Publications|
|Source:||Investigative Ophthalmology and Visual Science|
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