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Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation

Ono, R.; Kumagai, H.; Nakajima, H.; Hishiya, A.; Taki, T.; Horikawa, Keisuke; Takatsu, Kiyoshi; Satoh, T.; Hayashi, Y.; Kitamura, T.; Nosaka, T.

Description

Mixed-lineage-leukemia (MLL) fusion oncogenes are closely involved in infant acute leukemia, which is frequently accompanied by mutations or overexpression of FMS-like receptor tyrosine kinase 3 (FLT3). Earlier studies have shown that MLL fusion proteins

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/80331
Source: Leukemia
DOI: 10.1038/leu.2009.177

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