Brain-derived neurotrophic factor is expressed in a gradient in the superior colliculus during development of the retinocollicular projection
Theoretical models of topographic map formation have postulated a gradient of attractant in addition to a gradient of repulsion in the target. In species where many axons grow past their correct positions initially, it has also been argued that a parallel gradient of attractant or branching signal is required to ensure collateral formation at the correct position (O'Leary et al., 1999). Brain-derived neurotrophic factor (BDNF) is a known attractant and promotes branching of retinal axons. We...[Show more]
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|Source:||European Journal of Neuroscience|
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