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Multiple vulnerability of photoreceptors to mesopic ambient light in the P23H transgenic rat

Walsh, Natalie; van Driel, D; Lee, Donald; Stone, Jonathan


The P23H transgenic rat was engineered to mimic a human form of retinal degeneration caused by a mutation in rhodopsin. We have tested whether the P23H transgene influences the vulnerability of photoreceptors to modest variations in ambient light, well within the physiological range. P23H-3 (P23H line 3) and control Sprague-Dawley (SD) rats were raised in cyclic light (12 h light, 12 h dark), with the light phase set at either 5 lx ('scotopic-reared') or 40-60 lx ('mesopic-reared'). Mesopic...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Brain Research
DOI: 10.1016/j.brainres.2004.04.030


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