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Inhibitory modulation of photoreceptor melatonin synthesis via a nitric oxide-mediated mechanism

Wellard, John; Morgan, Ian

Description

Nitric oxide (NO) has been suggested to have many physiological functions in the vertebrate retina, including a role in light-adaptive processes. The aim of this study was to examine the influence of the NO-donor sodium nitroprusside (SNP) on the activity of arylalkylamine-N-acetyltransferase (AA-NAT; EC. 2.3.1.87), the activity of which responds to light and reflects the changes in retinal melatonin synthesis - a key feature of light-adaptive responses in photoreceptors. Incubation of...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/80267
Source: Neurochemistry International
DOI: 10.1016/j.neuint.2004.06.014

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