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SARS coronavirus E protein forms cation-selective ion channels

Wilson, Lauren; Mckinlay, Carolyn; Gage, Peter; Ewart, Gary


Severe Acute Respiratory Syndrome (SARS) is caused by a novel coronavirus (SARS-CoV). Coronaviruses including SARS-CoV encode an envelope (E) protein, a small, hydrophobic membrane protein. We report that, in planar lipid bilayers, synthetic peptides corresponding to the SARS-CoV E protein forms ion channels that are more permeable to monovalent cations than to monovalent anions. Affinity-purified polyclonal antibodies recognizing the N-terminal 19 residues of SARS-CoV E protein were used to...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Virology
DOI: 10.1016/j.virol.2004.09.033


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