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Genetic evidence that an endosymbiont-derived endoplasmic reticulum-associated protein degradation (ERAD) system functions in import of apicoplast proteins

Agrawal, Swati; van Dooren, Giel; Beatty, Wandy L.; Striepen, Boris


Most apicomplexan parasites harbor a relict chloroplast, the apicoplast, that is critical for their survival. Whereas the apicoplast maintains a small genome, the bulk of its proteins are nuclear encoded and imported into the organelle. Several models have been proposed to explain how proteins might cross the four membranes that surround the apicoplast; however, experimental data discriminating these models are largely missing. Here we present genetic evidence that apicoplast protein import...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M109.044024


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