Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity
-
Altmetric Citations
Description
The model that dendritic cell (DC) "maturation" describes the change from an immature, antigen-capturing cell to a mature, antigen-presenting cell is well-established. Classification of DCs in terms of function has been problematic previously. It is therefore proposed that mature and not immature DCs are responsible for antigen presentation and stimulation of T cells. Furthermore, DC antigen presentation to T cells can have two outcomes: tolerance or immunity. The particular outcomes appear to...[Show more]
dc.contributor.author | Tan, Jonathan | |
---|---|---|
dc.contributor.author | O'Neill, Helen | |
dc.date.accessioned | 2015-12-13T22:48:41Z | |
dc.date.available | 2015-12-13T22:48:41Z | |
dc.identifier.issn | 0741-5400 | |
dc.identifier.uri | http://hdl.handle.net/1885/80192 | |
dc.description.abstract | The model that dendritic cell (DC) "maturation" describes the change from an immature, antigen-capturing cell to a mature, antigen-presenting cell is well-established. Classification of DCs in terms of function has been problematic previously. It is therefore proposed that mature and not immature DCs are responsible for antigen presentation and stimulation of T cells. Furthermore, DC antigen presentation to T cells can have two outcomes: tolerance or immunity. The particular outcomes appear to be determined by the activation state of the mature DC. DCs can be activated by a range of environmental stimuli or "danger signals". Here, the hypothesis is advanced that activated, mature DCs induce T cell immunity, and resting, nonactivated but fully differentiated mature antigen-presenting DCs can induce tolerance. This proposal extends to conventional DCs and plasmacytoid DCs. The paper also concentrates on the spleen as a site for DC maturation, in light of evidence from this laboratory for differentiation of DCs from splenic precursors in longterm, stroma-dependent cultures. The hypothesis advanced here serves to simplify many current issues regarding DC maturation and function. | |
dc.publisher | Federation of American Societies for Experimental Biology | |
dc.source | Journal of Leukocyte Biology | |
dc.subject | Keywords: B7 antigen; CD11b antigen; CD86 antigen; CD8alpha antigen; double stranded RNA; glycoprotein p 15095; interleukin 12; interleukin 4; lipopolysaccharide; major histocompatibility antigen; major histocompatibility antigen class 1; major histocompatibility a Dendritic cell maturation; Spleen dendritic cells | |
dc.title | Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 78 | |
dc.date.issued | 2005 | |
local.identifier.absfor | 110704 - Cellular Immunology | |
local.identifier.ariespublication | MigratedxPub8491 | |
local.type.status | Published Version | |
local.contributor.affiliation | Tan, Jonathan, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | O'Neill, Helen, College of Medicine, Biology and Environment, ANU | |
local.bibliographicCitation.issue | 2 | |
local.bibliographicCitation.startpage | 319 | |
local.bibliographicCitation.lastpage | 324 | |
local.identifier.doi | 10.1189/jlb.1104664 | |
dc.date.updated | 2015-12-11T10:30:12Z | |
local.identifier.scopusID | 2-s2.0-23044451429 | |
Collections | ANU Research Publications |
Download
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator