Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity
The model that dendritic cell (DC) "maturation" describes the change from an immature, antigen-capturing cell to a mature, antigen-presenting cell is well-established. Classification of DCs in terms of function has been problematic previously. It is therefore proposed that mature and not immature DCs are responsible for antigen presentation and stimulation of T cells. Furthermore, DC antigen presentation to T cells can have two outcomes: tolerance or immunity. The particular outcomes appear to...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Leukocyte Biology|
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