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Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity

Tan, Jonathan; O'Neill, Helen

Description

The model that dendritic cell (DC) "maturation" describes the change from an immature, antigen-capturing cell to a mature, antigen-presenting cell is well-established. Classification of DCs in terms of function has been problematic previously. It is therefore proposed that mature and not immature DCs are responsible for antigen presentation and stimulation of T cells. Furthermore, DC antigen presentation to T cells can have two outcomes: tolerance or immunity. The particular outcomes appear to...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/80192
Source: Journal of Leukocyte Biology
DOI: 10.1189/jlb.1104664

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