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Comparative analysis and outcomes of sleeve resection versus pneumonectomy

Parissis, Harry; Leotsinidis, Michael; Hughes, Ann Maree; McGovern, Eillish; Luke, David; Young, Vincent

Description

To compare the outcome of sleeve resection or complex sleeve resection versus (Vs) pneumonectomy for lung cancer in a single unit. Between 1998 and 2006, 664 lung resections were carried out. There were 129 (19.4%) pneumonectomies and 79 (11.9%) sleeve resections; Twenty one patients (26.5%) underwent a complex sleeve resection. Operative mortality for the sleeve resections (SR) was 2.5% and for the pneumonectomies 8.53%. Overall 5-year survival after SR was 46.8% and after pneumonectomy 37.1%....[Show more]

dc.contributor.authorParissis, Harry
dc.contributor.authorLeotsinidis, Michael
dc.contributor.authorHughes, Ann Maree
dc.contributor.authorMcGovern, Eillish
dc.contributor.authorLuke, David
dc.contributor.authorYoung, Vincent
dc.date.accessioned2015-12-13T22:48:35Z
dc.identifier.issn0218-4923
dc.identifier.urihttp://hdl.handle.net/1885/80153
dc.description.abstractTo compare the outcome of sleeve resection or complex sleeve resection versus (Vs) pneumonectomy for lung cancer in a single unit. Between 1998 and 2006, 664 lung resections were carried out. There were 129 (19.4%) pneumonectomies and 79 (11.9%) sleeve resections; Twenty one patients (26.5%) underwent a complex sleeve resection. Operative mortality for the sleeve resections (SR) was 2.5% and for the pneumonectomies 8.53%. Overall 5-year survival after SR was 46.8% and after pneumonectomy 37.1%. The survival curves for the 2 procedures after adjusting for risk factors are different. The area under the curve is higher for the SR (Hazard ratio 1.78 C.I.: 0,92-3,46). The 5-year survival for early stages favors SR. The survival for the complex SR was not influenced by the complexity of the procedure but from the TNM stage of each individual case. Multivariate analysis of risk factors affecting survival after surgery showed: male sex Hazard ratio (HR) 1.19, 0.63-2.27(95%CI), Age >63 1.38(HR), 0.78-2.48, Pneumonectomy 1.78(HR), 0.92-3.46 and stage III 4.44(HR), 1.94-10.16(95% CI). For comparative stages survival appears to be better after sleeves, moreover male sex, sleeve resection, age younger that 63 and early TNM stage are positive predictors for survival.
dc.publisherSAGE Publications
dc.sourceAsian Cardiovascular and Thoracic Annals
dc.subjectKeywords: article; cancer staging; cancer surgery; comparative study; hazard ratio; histology; human; human tissue; Kaplan Meier method; lung cancer; lung non small cell cancer; lung resection; lung surgery; major clinical study; multivariate analysis; retrospectiv Carcinoma; Non-small-cell lung; Pneumonectomy; Thoracic surgical procedures
dc.titleComparative analysis and outcomes of sleeve resection versus pneumonectomy
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume17
dc.date.issued2009
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationf5625xPUB8467
local.type.statusPublished Version
local.contributor.affiliationParissis, Harry, University of Patras Medical School
local.contributor.affiliationLeotsinidis, Michael, University of Patras Medical School
local.contributor.affiliationHughes, Ann Maree, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMcGovern, Eillish, St. James’s Hospital
local.contributor.affiliationLuke, David, St. James’s Hospital
local.contributor.affiliationYoung, Vincent, St. James’s Hospital
local.description.embargo2037-12-31
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage175
local.bibliographicCitation.lastpage182
local.identifier.doi10.1177/0218492309103309
dc.date.updated2016-02-24T09:42:01Z
local.identifier.scopusID2-s2.0-70349229571
CollectionsANU Research Publications

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