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Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

VanBuskirk, Kelley M.; O'Neill, Matthew T.; De La Vega, Patricia; Maier, Alex; Krzych, Urszula; Williams, Jack; Dowler, Megan G.; Sacci, John B.; Kangwanrangsan, Niwat; Tsuboi, Takafumi; Knetem an, Norman M.; Heppner, Donald G.; Murdock, Brant A.; Mikolajczak, Sebastian A.; Aly, Ahmed S.I.; Cowman, Alan F.; Kappe, Stefan H.I.


Falciparum malaria is initiated when Anopheles mosquitoes transmit the Plasmodium sporozoite stage during a blood meal. Irradiated sporozoites confer sterile protection against subsequent malaria infection in animal models and humans. This level of protection is unmatched by current recombinant malaria vaccines. However, the live-attenuated vaccine approach faces formidable obstacles, including development of accurate, reproducible attenuation techniques. We tested whether Plasmodium falciparum...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0906387106


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