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Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumour cells

de Mestre, A; Rao, Sudha; Hornby, June; Soe-Htwe, Thura; Khachigian, Levon M; Hulett, Mark


Heparanase is an endoglycosidase that degrades heparan sulfate chains of heparan sulfate proteoglycans, a key component of extracellular matrix and basement membranes. Studies using heparanase inhibitors and gene silencing have provided evidence to support an important role for heparanase in tumor metastasis and angiogenesis. The expression of heparanase is normally very tightly controlled, however, it is commonly deregulated in tumor cells, which express elevated heparanase activity that...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M503414200


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