Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumour cells
Heparanase is an endoglycosidase that degrades heparan sulfate chains of heparan sulfate proteoglycans, a key component of extracellular matrix and basement membranes. Studies using heparanase inhibitors and gene silencing have provided evidence to support an important role for heparanase in tumor metastasis and angiogenesis. The expression of heparanase is normally very tightly controlled, however, it is commonly deregulated in tumor cells, which express elevated heparanase activity that...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Biological Chemistry|
|01_de Mestre_Early_growth_response_gene_1_2005.pdf||1.08 MB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.