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Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii

Schaeffer, Marie; Han, Seong-Ji; Chtanova, Tatyana; van Dooren, Giel; Herzmark, Paul; Chen, Ying; Roysam, Badrinath; Striepen, Boris; Robey, Ellen A.

Description

The intracellular parasite Toxoplasma gondii can establish persistent infection in the brain of a mammalian host, a standoff that involves the active participation of host CD8 T cells to control infection. CD8 T cells generally protect against intracellular pathogens by local delivery of effector molecules upon recognition of specific pathogen Ags on invaded host cells. However, the interactions between CD8 T cells, T. gondii, and APCs in the brain have not yet been examined. In this study we...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/80037
Source: Journal of Immunology
DOI: 10.4049/jimmunol.0804307

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