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Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1

Crowley, Emily; O'Mara, Megan; Reynolds, Catherine; Tieleman, D. Peter; Storm, Janet; Kerr, Ian; Callaghan, Richard


Multidrug efflux pumps, such as P-glycoprotein (ABCB1), present major barriers to the success of chemotherapy in a number of clinical settings. Molecular details of the multidrug efflux process by ABCB1 remain elusive, in particular, the interdomain communication associated with bioenergetic coupling. The present investigation has focused on the role of transmembrane helix 12 (TM12) in the multidrug efflux process of ABCB1. Cysteine residues were introduced at various positions within TM12, and...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Biochemistry
DOI: 10.1021/bi900373x


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