A newly discovered protein export machine in malaria parasites
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de Koning-Ward, Tania F.; Gilson, Paul R.; Boddey, Justin A.; Rug, Melanie; Smith, Brian J.; Papenfuss, Anthony T; Sanders, Paul R.; Lundie, Rachel J.; Maier, Alex; Cowman, A; Crabb, Brandan S.
Description
Several hundred malaria parasite proteins are exported beyond an encasing vacuole and into the cytosol of the host erythrocyte, a process that is central to the virulence and viability of the causative Plasmodium species. The trafficking machinery responsible for this export is unknown. Here we identify in Plasmodium falciparum a translocon of exported proteins (PTEX), which is located in the vacuole membrane. The PTEX complex is ATP-powered, and comprises heat shock protein 101 (HSP101; a...[Show more]
Collections | ANU Research Publications |
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Date published: | 2009 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/79987 |
Source: | Nature |
DOI: | 10.1038/nature08104 |
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01_de Koning-Ward_A_newly_discovered_protein_2009.pdf | 1.1 MB | Adobe PDF | Request a copy |
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