A newly discovered protein export machine in malaria parasites
de Koning-Ward, Tania F.; Gilson, Paul R.; Boddey, Justin A.; Rug, Melanie; Smith, Brian J.; Papenfuss, Anthony T; Sanders, Paul R.; Lundie, Rachel J.; Maier, Alex; Cowman, A; Crabb, Brandan S.
Several hundred malaria parasite proteins are exported beyond an encasing vacuole and into the cytosol of the host erythrocyte, a process that is central to the virulence and viability of the causative Plasmodium species. The trafficking machinery responsible for this export is unknown. Here we identify in Plasmodium falciparum a translocon of exported proteins (PTEX), which is located in the vacuole membrane. The PTEX complex is ATP-powered, and comprises heat shock protein 101 (HSP101; a...[Show more]
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