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Crystal structure of malaria parasite nucleosome assembly protein: Distinct modes of protein localization and histone recognition

Gill, Jasmita; Yogavel, Manickam; Kumar, Anuj; Belrhali, Hassan; Jain, S.K.; Rug, Melanie; Brown, Monica; Maier, Alex; Sharma, Amit

Description

Nucleosome assembly proteins (NAPs) are histone chaperones that are essential for the transfer and incorporation of histones into nucleosomes. NAPs participate in assembly and disassembly of nucleosomes and in chromatin structure organization. Human malaria parasite Plasmodium falciparum contains two nucleosome assembly proteins termed PfNapL and PfNapS. To gain structural insights into the mechanism of NAPs, we have determined and analyzed the crystal structure of PfNapL at 2.3 Å resolution....[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/79905
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M808633200

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