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Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells

Li, Rachel; Seto, Sai Wang; Au, Alice Lai Shan; Kwan, Yiu-Wa; Chan, Shun-Wan; Lee, Simon M.Y.; Tse, Chung-Ming; Leung, George P. H.


It is generally accepted that the clinical efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) arises mainly from the inhibition of cyclooxygenase (COX). However, more evidence has suggested that certain pharmacological actions of NSAIDs may be mediated by COX-independent mechanisms. The present study investigated the effects of NSAIDs on adenosine uptake in human aortic smooth muscle cells (HASMCs). Among the NSAIDs tested (all at 100 μM), aspirin, ibuprofen and naproxen had no effect on...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: European Journal of Pharmacology
DOI: 10.1016/j.ejphar.2009.04.017


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