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Deconvolution of insulin secretion, insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals: time course of glucose homeostasis in leptin replacement treatment.

Andreev, V P; Da Paz Filho, Gilberto; Wong, Ma-Li; Licinio, Julio


Minimally invasive methodology, mathematical model, and software for analysis of glucose homeostasis by deconvolution of insulin secretion, hepatic extraction, post-hepatic delivery, and sensitivity from 24-hour standardized meals test have been developed and illustrated by the study of glucose homeostasis of a genetically based leptin-deficient patient before and after leptin replacement treatment. The only genetically leptin-deficient adult man identified in the world was treated for 24...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Hormone and Metabolic Research
DOI: 10.1055/s-0028-1082048


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