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Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum

Maier, Alex; Baum, Jake; Smith, Brian J.; Conway, David J.; Cowman, Alan F.

Description

Invasion of human erythrocytes by the malaria parasite Plasmodium falciparum utilizes multiple ligand- receptor interactions involving erythrocyte receptors and parasite erythrocyte binding proteins of the Duffy binding-like family. Erythrocyte binding antigen 175 (EBA-175) binds to glycophorin A, the most abundant protein on the human erythrocyte surface and EBA-140 (also known as BAEBL) binds to glycophorin C, while the receptor for EBA-181 (also known as JESEBL) remains unknown. EBA binding...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/79843
Source: Infection and Immunity
DOI: 10.1128/IAI.01331-08

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