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Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine

Lee, Connie; Easton, Christopher; Savage, G Paul; Simpson, Gregory Wayne


Four spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo- and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.

CollectionsANU Research Publications
Date published: 2006
Type: Journal article


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