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Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine

Watt, Stephen J; Oakley, Aaron; Sheil, Margaret; Beck, Jennifer


The protein calmodulin (apoCaM) undergoes a conformational change when it binds calcium. This structure of the protein (Ca4CaM) is a dumbbell-shaped molecule that undergoes a further profound conformational change on binding of the antipsychotic drug trifluoperazine (TFP). Experimental conditions were developed to prepare samples of apoCaM, Ca4CaM and Ca4CaM/TFP that were substantially free of sodium. The effects of the conformational changes of calmodulin on the charge-state distributions...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Rapid Communications in Mass Spectrometry
DOI: 10.1002/rcm.2039


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