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A novel mechanism for complement activation at the surface of B cells following antigen binding

Manderson, A; Quah, Ben; Botto, Marina; Goodnow, Christopher; Walport, Mark J; Parish, Christopher


Coligation of CD21 with BCR on the surface of B cells provides a costimulatory signal essential for efficient Ab responses to T-dependent Ags. To achieve this, Ag must be directly linked to C3 fragments, but bow this occurs in vivo is not fully understood. Using BCR transgenic mice, we demonstrated that C3 was deposited on the surface of B cells following both high- and moderate-affinity Ag binding. This was dependent on the specific binding of IgM to the BCR-bound Ag and can occur...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Immunology


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