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An improved open-channel structure of MscL determined from FRET confocal microscopy and simulation

Corry, Ben; Hurst, Annette C.; Pal, Prithwish; Nomura, Takeshi; Rigby, Paul; Martinac, Boris


Mechanosensitive channels act as molecular transducers of mechanical force exerted on the membrane of living cells by opening in response to membrane bilayer deformations occurring in physiological processes such as touch, hearing, blood pressure regulation, and osmoregulation. Here, we determine the likely structure of the open state of the mechanosensitive channel of large conductance using a combination of patch clamp, fluorescence resonance energy transfer (FRET) spectroscopy, data from...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of General Physiology
DOI: 10.1085/jgp.200910376


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