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On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes

Franklin, Andrew; Blanden, Robert


Somatic hypermutation (SHM) diversifies the genes that encode immunoglobulin variable regions in antigen-activated germinal centre B lymphocytes. Available evidence strongly suggests that DNA deamination potentiates phase I SHM and subsequently triggers phase II SHM. A concise review of this evidence is followed by a detailed critique of two possible models which suggest that polymerase-η potentiates phase II SHM via either its DNA-dependent or its RNA-dependent DNA synthetic activity....[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1111/j.1440-1711.2004.01289.x


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