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Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1

Crowley, Emily; O'Mara, Megan; Kerr, Ian; Callaghan, Richard


Describing the molecular details of the multidrug efflux process of ABCB1, in particular the interdomain communication associated with bioenergetic coupling, continues to prove difficult. A number of investigations to date have implicated transmembrane helix 12 (TM12) in mediating communication between the transmembrane domains and nucleotide-binding domains (NBDs) of ABCB1. The present investigation further addressed the role of TM12 in ABCB1 by characterizing its topography during the...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: The FEBS Journal
DOI: 10.1111/j.1742-4658.2010.07789.x


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