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Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte

Kulzer, Simone; Rug, Melanie; Brinkmann, Klaus; Cannon, Ping Z; Cowman, Alan F.; Lingelbach, Klaus; Blatch, Gregory L; Maier, Alex; Przyborski, Jude M

Description

Plasmodium falciparum is predicted to transport over 300 proteins to the cytosol of its chosen host cell, the mature human erythrocyte, including 19 members of the Hsp40 family. Here, we have generated transfectant lines expressing GFP- or HA-Strep-tagged versions of these proteins, and used these to investigate both localization and other properties of these Hsp40 co-chaperones. These fusion proteins labelled punctate structures within the infected erythrocyte, initially suggestive of a...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/79442
Source: Cellular Microbiology
DOI: 10.1111/j.1462-5822.2010.01477.x

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