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Molecular definition of an in vitro niche for dendritic cell development

Despars, Genevieve; Ni, Keping; Bouchard, Antoine; O'Neill, Terence; O'Neill, Helen


Although dendritic cell (DC) precursors have been isolated from many lymphoid sites, the regulation and location of early DC development is still poorly understood. Here we describe a splenic microenvironment that supports DC hematopoiesis in vitro and identify gene expression specific for that niche. The DC supportive function of the STX3 splenic stroma and the lymph node-derived 2RL22 stroma for overlaid bone marrow cells was assessed by coculture over 2 weeks. The DC supportive function of...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Experimental Hematology
DOI: 10.1016/j.exphem.2004.08.013


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