Molecular definition of an in vitro niche for dendritic cell development
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Despars, Genevieve; Ni, Keping; Bouchard, Antoine; O'Neill, Terence; O'Neill, Helen
Description
Although dendritic cell (DC) precursors have been isolated from many lymphoid sites, the regulation and location of early DC development is still poorly understood. Here we describe a splenic microenvironment that supports DC hematopoiesis in vitro and identify gene expression specific for that niche. The DC supportive function of the STX3 splenic stroma and the lymph node-derived 2RL22 stroma for overlaid bone marrow cells was assessed by coculture over 2 weeks. The DC supportive function of...[Show more]
Collections | ANU Research Publications |
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Date published: | 2004 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/79365 |
Source: | Experimental Hematology |
DOI: | 10.1016/j.exphem.2004.08.013 |
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01_Despars_Molecular_definition_of_an_in_2004.pdf | 331.49 kB | Adobe PDF | Request a copy |
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