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Magnesium sulfate fails to reduce infarct volume following transient focal cerebral ischemia in rats

Zhu, Hong-Dong; Martin, Rosemary; Meloni, Bruno; Oltvolgyi, Csongor; Moore, Stephen; Majda, Bernadette; Knuckey, Neville


Studies on the neuroprotective effect of magnesium treatment in animal models of focal and global cerebral ischemia have produced inconsistent results. Nevertheless, two magnesium acute stroke phase III trials (IMAGES and FAST-MAG) have either been completed or are planned. Therefore, we decided to re-evaluate the efficacy of magnesium following focal cerebral ischaemia in rats. Two experiments were carried out in two independent laboratories based in Australia. Both used the intraluminal...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Neuroscience Research
DOI: 10.1016/j.neures.2004.04.001


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