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The prion protein gene: Identifying regulatory signals using marsupial sequence

Premzl, Marko; Delbridge, Margaret; Gready, Jill; Wilson, Peter; Johnson, Matthew; Davis, John; Kuczek, Elizabeth; Graves, Jennifer

Description

The function of the prion protein gene (PRNP) and its normal product PrPC is elusive. We used comparative genomics as a strategy to understand the normal function of PRNP. As the reliability of comparisons increases with the number of species and increased evolutionary distance, we isolated and sequenced a 66.5 kb BAC containing the PRNP gene from a distantly related mammal, the model Australian marsupial Macropus eugenii (tammar wallaby). Marsupials are separated from eutherians such as human...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/79259
Source: Gene
DOI: 10.1016/j.gene.2004.11.049

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