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Characterisation of the marsupial-specific ATRY gene: Implications for the evolution of male-specific function

Park, Daniel J; Pask, Andrew J; Huynh, Kim; Harley, Vincent R; Renfree, Marilyn B; Graves, Jennifer


Many or most genes on the mammal Y chromosome evolved a testis-specific function after diverging from an X-borne copy with a general function in both sexes. In marsupial but not eutherian mammals, a testis-specific orthologue (ATRY) of the widely expressed X-borne ATRX gene lies on the Y chromosome. Since mutations in human ATRX cause sex reversal, it is possible that one function of ATRY in marsupials is testicular differentiation. We report here the isolation and sequencing of the tammar...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Gene
DOI: 10.1016/j.gene.2005.08.003


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