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Tumor necrosis factor (TNF) and lymphotoxin-a (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium

Skibola, Christine F; Bracci, Paige M; Nieters, Alexander; Brooks-Wilson, Angela; de Sanjose, Silvia; Hughes, Ann Maree; Cerhan, James R; Skibola, Danica R; Purdue, Mark; Kane, Eleanor; Lan, Qing; Foretova, Lenka; Schenk, Maryjean; Spinelli, John J; Slager, Susan L; De Roos, Anneclaire J; Smith, Martyn T; Roman, Eve; Cozen, Wendy; Boffetta, Paolo; Kricker, Anne; Zheng, Tongzhang; Lightfoot, Tracy; Cocco, Pierluigi; Benavente, Yolanda; Zhang, Yawei; Hartge, Patricia; Linet, Martha S; Becker, Nikolaus; Brennan, Paul; Zhang, Luoping; Armstrong, Bruce K; Smith, Alex; Shiao, Renee; Novak, Anne J; Maynadie, Marc; Chanock, Stephen J; Staines, Anthony; Holford, Theodore R; Holly, Elizabeth A; Rothman, Nathaniel; Wang, Sophia S


In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF-308G>A (rs1800629), lymphotoxin-α (LTA) 252A>G (rs909253), IL10-3575T>A (rs1800890,...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwp383


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