Brooks, Carrie F; Johnsen, Hanne; van Dooren, Giel; Muthalagi, Mani; Lin, San San; Bohne, Wolfgang; Fischer, Karsten; Striepen, Boris
Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosphate translocator (TgAPT) is an essential metabolic link between the endosymbiont and the parasite cytoplasm. TgAPT is required for fatty acid synthesis in the apicoplast, but this...[Show more]
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