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Influence of personal characteristics of individual women on sensitivity and specificity of mammography in the Million Women Study: cohorty study.

Banks, Emily; Reeves, Gillian K; Beral, Valerie; Bull, Diana; Crossley, Barbara; Simmonds, Moya; Hilton, Elizabeth; Bailey, Stephen; Barrett, Nigel; Briers, Peter; English, Ruth; Jackson, Alan; Kutt, Elizabeth; Lavelle, Janet; Rockall, Linda; Wallis, Matthew G; Wilson, Mary; Patrick, Julietta

Description

Objectives: To examine how lifestyle, hormonal, and other factors influence the sensitivity and specificity of mammography. Methods: Women recruited into the Million Women Study completed a questionnaire about various personal factors before routine mammographic screening. A sample of 122 355 women aged 50-64 years were followed for outcome of screening and incident breast cancer in the next 12 months. Sensitivity and specificity were calculated by using standard definitions, with adjustment...[Show more]

dc.contributor.authorBanks, Emily
dc.contributor.authorReeves, Gillian K
dc.contributor.authorBeral, Valerie
dc.contributor.authorBull, Diana
dc.contributor.authorCrossley, Barbara
dc.contributor.authorSimmonds, Moya
dc.contributor.authorHilton, Elizabeth
dc.contributor.authorBailey, Stephen
dc.contributor.authorBarrett, Nigel
dc.contributor.authorBriers, Peter
dc.contributor.authorEnglish, Ruth
dc.contributor.authorJackson, Alan
dc.contributor.authorKutt, Elizabeth
dc.contributor.authorLavelle, Janet
dc.contributor.authorRockall, Linda
dc.contributor.authorWallis, Matthew G
dc.contributor.authorWilson, Mary
dc.contributor.authorPatrick, Julietta
dc.date.accessioned2015-12-13T22:42:47Z
dc.date.available2015-12-13T22:42:47Z
dc.identifier.issn0959-535X
dc.identifier.urihttp://hdl.handle.net/1885/78915
dc.description.abstractObjectives: To examine how lifestyle, hormonal, and other factors influence the sensitivity and specificity of mammography. Methods: Women recruited into the Million Women Study completed a questionnaire about various personal factors before routine mammographic screening. A sample of 122 355 women aged 50-64 years were followed for outcome of screening and incident breast cancer in the next 12 months. Sensitivity and specificity were calculated by using standard definitions, with adjustment for potential confounding factors. Results: Breast cancer was diagnosed in 726 (0.6%) women, 629 in screen positive and 97 in screen negative women; 3885 (3.2%) were screen positive but had no subsequent diagnosis of breast cancer. Overall sensitivity was 86.6% and specificity was 96.8%. Three factors had an adverse effect on both measures: use of hormone replacement therapy (sensitivity: 83.0% (95% confidence interval 77.4% to 87.6%), 84.7% (73.9% to 91.6%), and 92.1% (87.6% to 95.0%); specificity: 96.8% (96.6% to 97.0%), 97.8% (97.5% to 98.0%), and 98.1% (98.0% to 98.2%), respectively, for current, past, and never use); previous breast surgery v no previous breast surgery (sensitivity: 83.5% (75.7% to 89.1%) v 89.4% (86.5% to 91.8%); specificity: 96.2% (95.8% to 96.5%) v 97.4% (97.3% to 97.5%), respectively); and body mass index <25 v ≥25 (sensitivity: 85.7% (81.2% to 89.3%) v 91.0% (87.5% to 93.6%); specificity: 97.2% (97.0% to 97.3%) v 97.4% (97.3% to 97.6%), respectively). Neither sensitivity nor specificity varied significantly according to age, family history of breast cancer, parity, past oral contraceptive use, tubal ligation, physical activity, smoking, or alcohol consumption. Conclusions: The efficiency, and possibly the effectiveness, of mammographic screening is lower in users of hormone replacement therapy, in women with previous breast surgery, and in thin women compared with other women.
dc.publisherBMJ Publishing Group
dc.sourceBMJ - British Medical Journal
dc.subjectKeywords: estrogen; progesterone; adult; age distribution; alcohol consumption; anamnesis; article; breast carcinoma; breast surgery; cancer hormone therapy; cancer screening; confidence interval; controlled study; diagnostic accuracy; echomammography; family histo
dc.titleInfluence of personal characteristics of individual women on sensitivity and specificity of mammography in the Million Women Study: cohorty study.
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume329
dc.date.issued2004
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationMigratedxPub7467
local.type.statusPublished Version
local.contributor.affiliationBanks, Emily, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationReeves, Gillian K, University of Oxford
local.contributor.affiliationBeral, Valerie, University of Oxford
local.contributor.affiliationBull, Diana, University of Oxford
local.contributor.affiliationCrossley, Barbara, University of Oxford
local.contributor.affiliationSimmonds, Moya, University of Oxford
local.contributor.affiliationHilton, Elizabeth, University of Oxford
local.contributor.affiliationBailey, Stephen, Princess of Wales Community Hospital
local.contributor.affiliationBarrett, Nigel, Charing Cross Hospital
local.contributor.affiliationBriers, Peter, Gloucestershire Breast Screening Service
local.contributor.affiliationEnglish, Ruth, Radcliffe Infirmary
local.contributor.affiliationJackson, Alan, Queen Alexandra Hospital UK
local.contributor.affiliationKutt, Elizabeth, Central Health Clinic
local.contributor.affiliationLavelle, Janet, Royal Lancaster Infirmary
local.contributor.affiliationRockall, Linda, Worthing Hospital
local.contributor.affiliationWallis, Matthew G, Coventry and Warwick Hospital
local.contributor.affiliationWilson, Mary, Withington Hospital
local.contributor.affiliationPatrick, Julietta, National Health Service Cancer Screening Programmes
local.bibliographicCitation.issue7464
local.bibliographicCitation.startpage477
dc.date.updated2015-12-11T10:09:01Z
local.identifier.scopusID2-s2.0-4344698328
CollectionsANU Research Publications

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