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Preoptic hypothalamic warming suppresses laryngeal dilator activity during sleep

McGinty, Dennis; Metes, Agnes; Alam, Noor; Megirian, David; Steward, Darya; Szymusiak, Ron


Upper airway dilator activity during sleep appears to be diminished under conditions of enhanced sleep propensity, such as after sleep deprivation, leading to worsening of obstructive sleep apnea (OSA). Non-rapid eye movement (NREM) sleep propensity originates in sleep-active neurons of the preoptic area (POA) of the hypothalamus and is facilitated by activation of POA warm-sensitive neurons (WSNs). We hypothesized that activation of WSNs by local POA warming would inhibit activity of the...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
DOI: 10.1152/ajpregu.00296.2003


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