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Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1

Ranasinghe, Charani; Medveczky, C; Woltring, Donna; Gao, Ke; Thomson, Scott; Coupar, Barbara E H; Boyle, Brian John; Ramsay, Alistair; Ramshaw, Ian

Description

We have tested the efficacy of recombinant fowl pox (rFPV) and recombinant vaccinia virus (rVV) encoding antigens of AE clade HIV-1 in a prime-boost strategy, using both systemic and mucosal delivery routes. Of the various vaccine routes tested, intranasal/intramuscular (i.n./i.m.) AE FPV/AE VV prime-boosting generated the highest mucosal and systemic T cell responses. Peak mucosal T cell responses occurred as early as 3 days post-boost vaccination. In contrast only low systemic responses were...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/78866
Source: Vaccine
DOI: 10.1016/j.vaccine.2006.04.023

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