Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1
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Medveczky, C; Woltring, Donna; Gao, Ke; Thomson, Scott; Coupar, Barbara E H; Boyle, Brian John; Ramsay, Alistair; Ramshaw, Ian; Ranasinghe, Charani
Description
We have tested the efficacy of recombinant fowl pox (rFPV) and recombinant vaccinia virus (rVV) encoding antigens of AE clade HIV-1 in a prime-boost strategy, using both systemic and mucosal delivery routes. Of the various vaccine routes tested, intranasal/intramuscular (i.n./i.m.) AE FPV/AE VV prime-boosting generated the highest mucosal and systemic T cell responses. Peak mucosal T cell responses occurred as early as 3 days post-boost vaccination. In contrast only low systemic responses were...[Show more]
Collections | ANU Research Publications |
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Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/78866 |
Source: | Vaccine |
DOI: | 10.1016/j.vaccine.2006.04.023 |
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01_Ranasinghe_Evaluation_of_fowlpox-vaccinia_2006.pdf | 879.38 kB | Adobe PDF | Request a copy |
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