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A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome

Acosta, MT; Velez, JI; Bustamante, ML; Balog, J.; Arcos-Burgos, Mauricio (Oscar); Muenke, Maximilian

Description

The severity of attention-deficit/hyperactivity disorder (ADHD) symptoms is a major predictor of long-term ADHD outcome. To investigate if two-locus interactions might predict ADHD severity, we studied a sample of 1341 individuals from families clustering ADHD, using the Vanderbilt Assessment Scale for Parents. Latent class cluster analysis was used to construct symptom profiles and classify ADHD severity. Single nucleotide polymorphisms (SNPs) spanning ADHD-linked chromosomal regions on...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/78744
Source: Translational Psychiatry
DOI: 10.1038/tp.2011.14

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