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The effect of membrane curvature on the conformation of antimicrobial peptides: Implications for binding and the mechanism of action

Chen, Rong; Mark, Alan

Description

Short cationic antimicrobial peptides (AMPs) are believed to act either by inducing transmembrane pores or disrupting membranes in a detergent-like manner. For example, the antimicrobial peptides aurein 1.2, citropin 1.1, maculatin 1.1 and caerin 1.1, despite being closely related, appear to act by fundamentally different mechanisms depending on their length. Using molecular dynamics simulations, the structural properties of these four peptides have been examined in solution as well as in a...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/78642
Source: European Biophysics Journal
DOI: 10.1007/s00249-011-0677-4

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