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The Novel Chelator lipid 3(nitrilotriacetic acid)-ditetradecylamine (NTA3-DTDA) promotes stable binding of His-tagged proteins to liposomal membranes: Potent anti-tumor responses induced by simultaneously targeting antigen, cytokine and costimulatory signals to T cells.

Van Broekhoven, Christina; Altin, Joseph


Recent studies indicate that the chelator lipid nitrilotriacetic acid ditetradecylamine (NTA-DTDA) can be used to engraft T cell costimulatory molecules onto tumor cell membranes, potentially circumventing the need for genetic manipulation of the cells for development of cell- or membrane-based tumor vaccines. Here, we show that a related lipid 3(nitrilotriacetic acid)-ditetradecylamine (NTA3-DTDA, which has three NTA moieties in its headgroup instead of one) is several-fold more effective than...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Biochimica et Biophysica Acta: Biomembranes
DOI: 10.1016/j.bbamem.2005.09.003


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