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From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders

Martinez, Ariel F; Muenke, Maximilian; Arcos-Burgos, Mauricio (Oscar)


The findings of a recent study associate LPHN3, a member of the latrophilin family, with an increased risk of developing attention deficit/hyperactivity disorder (ADHD), the most common psychiatric disorder in childhood and adolescence. Latrophilins comprise a new family of G protein-coupled receptors of unknown native physiological function that mediate the neurotoxic effects of α-latrotoxin, a potent toxin found in black widow spider venom. This receptor-toxin interaction has helped to...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: American Journal of Medical Genetics, Part B: Neuropsychiatric
DOI: 10.1002/ajmg.b.31137


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