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Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives

Wang, Shuxiang; Shao, Wenqing; Li, Hongdong; Liu, Cui; Wang, Ke; Zhang, Jinchao


Eight new gold(III) complexes (1-8) of 5-aryl-3-(pyridin-2-yl)-4,5- dihydropyrazole-1-carbothioamide have been synthesized and characterized by elemental analysis, molar conductivity, IR, UV,1H NMR,13C NMR, MS, and thermal analysis techniques. The cytotoxicity was tested by MTT assay. The results indicate that the complexes 1-8 exert cytotoxic effects against HeLa and A549 cell lines. Moreover, the complexes 1, 4, 5, 7 and 8 have higher cytotoxicity than cisplatin against HeLa cell line. It...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: European Journal of Medicinal Chemistry
DOI: 10.1016/j.ejmech.2011.02.031


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