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The orphan transporter v7-3 (slc6a15) is a Na + -dependent neutral amino acid transporter (B 0 AT2)

Broer, Angelika; Tietze, Nadine; Kowalczuk, Sonja; Chubb, Sarah; Kingsland (previously Munzinger), Michael; Bak, Lasse; Broer, Stefan

Description

Transporters of the SLC6 (solute carrier 6) family play an important role in the removal of neurotransmitters in brain tissue and in amino acid transport in epithelial cells. In the present study, we demonstrate that mouse v7-3 (slc6a15) encodes a transporter for neutral amino acids. The transporter is functionally and sequence related to B0AT1 (slc6a19) and was hence named B°AT2. Leucine, isoleucine, valine, proline and methionine were recognized by the transporter, with values of K0.5...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/78519
Source: Biochemical Journal
DOI: 10.1042/BJ20051273

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