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Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy

Stanescu, Horia C.; Arcos-Burgos, Mauricio (Oscar); Medlar, Alan; Bockenhauer, Detlef; Kottgen, Anna; Dragomirescu, Liviu; Catalin, Voinescu; Pearce, Kerra; Hubank, Mike; Stephens, Henrey A.F.

Description

BACKGROUND: Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of biopsy-proven cases of idiopathic membranous nephropathy in a white population. METHODS: We performed independent genomewide association studies of single-nucleotide polymorphisms (SNPs) in patients with idiopathic membranous nephropathy from three populations of white ancestry (75 French, 146 Dutch, and 335...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/78504
Source: New England Journal of Medicine
DOI: 10.1056/NEJMoa1009742

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